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Polyketide synthases (PKSs) are a family of multi-domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites, in bacteria, fungi, plants, and a few animal lineages. The biosyntheses of polyketides share striking similarities with fatty acid biosynthesis. The PKS genes for a certain polyketide are usually organized in one operon in bacteria and in gene clusters in eukaryotes. ==Classification== PKSs can be classified into three groups: * Type I polyketide synthases are large, highly modular proteins. * Type II polyketide synthases are aggregates of monofunctional proteins. * Type III polyketide synthases do not use ACP domains. Type I PKSs are further subdivided: * Iterative PKSs reuse domains in a cyclic fashion. * Modular PKSs contain a sequence of separate modules and do not repeat domains (with the exception of trans-AT domains). Iterative PKSs (IPKSs) can be still further subdivided: * NR-PKSs — non-reducing PKSs, the products of which are true polyketides * PR-PKSs — partially reducing PKSs * FR-PKSs — fully reducing PKSs, the products of which are fatty acid derivatives 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Polyketide synthase」の詳細全文を読む スポンサード リンク
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